LONDON (TIP): The most extensive genetic study ever conducted of Charles Darwin’s finches from the Galapagos Islands, has revealed a messy family tree with a surprising level of interbreeding between species. It also suggests that changes in one particular gene triggered the wide variation seen in their beak shapes.
Scientists in Sweden and the US used genome sequences of 120 individual birds from 17 different species to perform their analysis. Researchers from Princeton University and Uppsala University in Sweden have identified a gene in the Galapagos finches studied by English naturalist Charles Darwin that influences beak shape and that played a role in the birds’ evolution from a common ancestor more than 1 million years ago.
The study illustrates the genetic foundation of evolution, including how genes can flow from one species to another, and how different versions of a gene within a species can contribute to the formation of entirely new species.
The study was published on February 11, one day before birthday of Darwin, who studied the finches during the 1835 voyage that would lead him to publish the seminal work on evolution, “On the Origin of Species,” in 1859.
“We now know more about the genetic basis for our evolutionary studies, and this is a highly satisfactory, very exciting discovery after all these years,” said Peter Grant, Princeton’s professor of zoology.
Grant has studied the finches for 40 years on the arid, rocky islands of Daphne Major and Genovesa in the Galapagos archipelago. The latest study reveals how evolution occurs in halting and disordered steps, with many opportunities for genes to spread in different species and create new lineages. Given the right conditions, such as isolation from the original population and an accumulation of genetic differences, these lineages can eventually evolve into entirely new species.
Working with DNA samples collected by the Grants, researchers at Uppsala identified the gene that influences beak shape by comparing the genomes of 120 birds, all members of the 15 species known as “Darwin’s finches.” They spotted a stretch of DNA that looked different in species with blunt beaks, such as the large ground finch versus species with pointed beaks, such as the large cactus finch.
Within that stretch of DNA, the researchers found a gene known as ALX1, which has previously been identified in humans and mice as being associated with the formation of facial features. Mutations that inactivate this gene cause severe birth defects in humans.
“This is an interesting example where mild mutations in a gene that is critical for normal development leads to phenotypic (observable) evolution,” said lead researcher Leif Andersson, a professor of functional genomics at Uppsala University.
But the most exciting and interesting finding of the study, Andersson said, was that the gene also varied among individuals from the same species. For example, the medium ground finch species includes some birds with blunt beaks and others with pointed ones. This finding is significant because it shows how evolution can happen, Peter Grant said. Within a species, when some individuals have a trait that aids their survival — such as a blunt beak that allows them to crack open tough seed coverings — they will pass on the genes for that trait to their offspring, whereas individuals with pointed beaks will have died.
“This is the genetic variation upon which natural selection can work,” he said.
The shape and size of the beak are crucial for finch survival on the islands, which periodically experience extreme droughts, El Nino-driven rains and volcanic activity. The birds use their beaks as tools to crack open the hard and woody outer coverings of seeds, pry insects from twigs, and sip nectar from cactus flowers. In times of drought, a bird that can extract food from multiple sources will survive whereas other birds will not.
