NEW YORK (TIP): Five Indian Americans are among nearly 80 preeminent women in business, along with select leaders in government, philanthropy, education, sports, and the arts, who will speak at the 2022 Fortune Most Powerful Women Summit.

This year’s theme, “Realizing Your Power,” will be threaded through the three-day event at the Ritz-Carlton, Laguna Niguel, New York on Oct 10-12.in conversations with speakers, Fortune announced Tuesday.

The event features more than 25 CEOs and 65 C-suite professionals, as well as founders, board members and US Representatives, Liz Cheney of Wyoming, and Katie Porter from the 45th District of California.

The Indian American speakers include Amrita Ahuja, Chief Financial Officer, Block; Tarika Barrett, Chief Executive Officer, Girls Who Code; Dr. Sumbul Ahmad Desai, Vice President, Health, Apple; Reshma Saujani, Guest Co-chair, Fortune MPW Summit; Founder and CEO, Girls Who Code: Shamina Singh, Founder and President, Center for Inclusive Growth and EVP, Sustainability, Mastercard; and Manjula Talreja, Senior Vice President and Chief Customer Officer, PagerDuty.

Started more than 20 years ago as an annual list in the magazine, Fortune MPW has evolved into an extraordinary leadership community, convening its members throughout the year for wide-ranging conversations that inspire and deliver practical advice, according to a press release. This year’s Summit will explore this new era for both business and leaders, diving into how recent crises have forced leaders to reassess priorities and values, both personally and professionally—and the opportunity and empowerment that comes with that reevaluation.

Programming will address some recent difficult and controversial issues head-on, from regulatory crackdown to restrictions on reproductive health, and it will explore how leaders are responding, and what they can learn from each other, the release said.