Tag: Omicron

  • March 25 New York & Dallas E – Edition

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  • Omicron infection linked with common respiratory illness in children: Study

    Omicron infection linked with common respiratory illness in children: Study

    Infection with the Omicron variant of the SARS-CoV-2 virus is associated with a common respiratory illness in young children, known as croup, a previously unrecognised complication of COVID-19, according to a study.

    The observational study, published recently in the journal Pediatrics, describes 75 children who came to the Boston Children’s Hospital emergency department (ED) with croup and COVID-19 from March 1, 2020, to January 15, 2022.

    The researchers noted that some cases were surprisingly severe, requiring hospitalisation and more medication doses compared to croup caused by other viruses, adding that just over 80 per cent occurred during the Omicron period.

    “There was a very clear delineation from when Omicron became the dominant variant to when we started seeing a rise in the number of croup patients,” said study first author Ryan Brewster, from Boston Children’s Hospital and Boston Medical Center.

    Croup, also known as laryngotracheitis, is a common respiratory illness in babies and young children. The illness is marked by a distinctive barking cough and sometimes noisy, high-pitched intakes of breath known as stridor. It happens when colds and other viral infections cause inflammation and swelling around the voice box, windpipe, and bronchial tubes. In severe cases, including some seen at Boston Children’s, croup can dangerously constrict breathing, the researchers said. Previous studies of COVID-19 in animals have found that the Omicron variant has more of a “preference” for the upper airway than earlier variants, which mainly targeted the lower respiratory tract. This may account for the sudden appearance of croup during the Omicron surge, Brewster said. Most of the children with COVID-19 and croup were under age 2, and 72 per cent were boys. Except for one child with a common cold virus, all others were infected with SARS-CoV-2. Although no children died, nine of the 75 children with COVID-19-associated croup (12 per cent) needed to be hospitalised and four of them (44 per cent, or 5 per cent of the total) required intensive care, the researchers said.    Source: PTI

  • March 18 New York & Dallas E – Edition

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  • Indian-origin physician Ashish Jha is Biden’s COVID-19 response chief

    Indian-origin physician Ashish Jha is Biden’s COVID-19 response chief

    WASHINGTON D.C.  (TIP): Ashish Jha, an Indian-origin physician and public health specialist from Brown University, has been appointed the new White House COVID-19 Response Coordinator. Dr. Jha will replace Jeff Zeints, who has led the Biden administration’s pandemic response thus far, U.S. President Joe Biden said in a statement on Thursday, March 17. “Dr. Jha is one of the leading public health experts in America, and a well-known figure to many Americans from his wise and calming public presence. And as we enter a new moment in the pandemic — executing on my National COVID-19 Preparedness Plan and managing the ongoing risks from COVID — Dr. Jha is the perfect person for the job,” Mr. Biden said. He also praised Mr. Zeints for his efforts in setting up the infrastructure to fight the pandemic.

    “He is a man of service and an expert manager,” Mr. Biden said. Dr. Jha , who is the Dean of the Brown University School of Public Health has worked on Ebola and was a co-chair of a commission to tackle an outbreak of the disease in West Africa in 2014 , according to a biography from Brown University. Dr. Jha will take over the role at a time when close to a million Americans have died from COVID-19. The U.S. has just witnessed a wave of the Omicron variant, even as news of a new subvariant BA.2 — causing surges of the pandemic in Europe — is being watched closely. Two years into the pandemic and with three quarters of its population having received a single dose of the vaccine, the country is shifting to a different approach to managing COVID-19 as it shows signs of becoming endemic.“We still have important work to do to protect Americans’ lives and wellbeing,” Dr. Jha said on Twitter, as he acknowledged that “a lot” of progress had been made already.

    (Source: The Hindu)

  • March 11 New York & Dallas E – Edition

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  • March 4 New York & Dallas E – Edition

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  • February 25 New York & Dallas E – Edition

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  • February 18 New York & Dallas E – Edition

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  • February 11 New York & Dallas E – Edition

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  • February 4 New York & Dallas E – Edition

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  • Omicron sub-lineage BA.2 variant under investigation in UK

    The UK health authorities on Friday said they will be conducting further analysis into a sub-lineage of the Omicron variant of Covid-19 after designating it a variant under investigation (VUI).

    The UK Health Security Agency (UKHSA), which monitors data related to the pandemic, said the sub-lineage known as BA.2 shows a low number of cases in the country, with the original Omicron lineage BA.1 still dominant.

    A VUI designation is the initial step of investigation before being designated a variant of concern (VOC), which the original Omicron BA.1 currently is.

    “The Omicron variant sub-lineage known as BA.2 has been designated as a variant under investigation,” UKHSA said.

    “The number of BA.2 cases is currently low, with the original Omicron lineage, BA.1, still dominant in the UK and further analyses will now be undertaken. UKHSA are continuing to monitor data on the BA.2 sub-lineage closely,” it said. The sub-lineage was designated in early December last year and as of January 10 this year, 53 sequences of BA.2 had been identified in the UK.

    “It is in the nature of viruses to evolve and mutate, so it’s to be expected that we will continue to see new variants emerge as the pandemic goes on,” said Dr Meera Chand, UKHSA Incident Director.

    “Our continued genomic surveillance allows us to detect them and assess whether they are significant. Case rates remain high throughout the UK and we must remain vigilant and take up vaccinations,” she said.

    The UKHSA update comes as the UK recorded another 107,364 Covid-19 infections on Thursday, after having dropped below the 100,000 mark in recent days. The health agency said there is now “high confidence” that the Omicron variant causes low severity of disease in adults. However, confidence levels for severity indicators for children are low because further analysis is required to compare the risk of hospitalisation between Omicron and Delta, and to assess the clinical nature of illness in children.

    Source: PTI

  • Omicron wave is wake-up call about need to vaccinate the world, say Hill Democrats, experts

    Omicron wave is wake-up call about need to vaccinate the world, say Hill Democrats, experts

    WASHINGTON, D.C. (TIP): Senior administration officials, public health experts and Democrats say that the omicron wave has illustrated gaps in the U.S. global coronavirus strategy, warning that low-income nations are particularly vulnerable to the virus and that the risk of another variant will remain elevated as long as billions of people are unvaccinated, Washington Post reported. “The assignment is incomplete,” said Rep. Raja Krishnamoorthi (D-Ill.), who is leading a group of Democrats calling for $17 billion in additional funding for global vaccination delivery and infrastructure to immunize people in the developing world. “We need to make this investment going forward, and we need to do it ASAP.” Some lawmakers and officials also say they remain unhappy with President Biden’s decision to split authority over the global coronavirus strategy between White House covid-19 response coordinator Jeff Zients and national security adviser Jake Sullivan, arguing the structure complicates decisions and forces the two men to navigate between competing crises. Zients’s team has recently focused on the surging U.S. outbreak, and Sullivan’s national security team is addressing threats such as Russia’s potential invasion of Ukraine.

    “I think we need somebody whose mission 24/7 is to help get the rest of the world vaccinated,” Krishnamoorthi said. “The consequences are enormous. We found out — painfully — how quickly a variant can come over here from abroad and totally overwhelm our system.”

    About 10 billion doses of coronavirus vaccine have been administered around the world, but they have been concentrated in wealthy nations, according to a World Health Organization review shared with The Washington Post. High-income countries have administered about 14 times the number of doses per inhabitant compared with low-income countries, the WHO found. About 84 percent of the population of the African Union has yet to receive a single shot, even as about 40 percent of Americans have received booster shots, according to The Post’s vaccine tracker. The Biden administration maintains that its leadership structure is working and that its global strategy — focused on donating vaccine doses abroad — remains unchanged, despite omicron’s ability to evade some immune protection conferred by vaccines. The United States has now donated about 390 million doses to other countries, far more than any other nation, with Biden pressing global leaders to ramp up their donations.

    “We know what works, and it’s vaccines. And we’re leaning into that hard,” said a senior administration official who was not authorized to discuss the issue publicly and spoke on the condition of anonymity. “The science is clear. Vaccines are protecting, particularly when boosters are deployed.”

    The United States is also helping fund efforts to increase vaccine manufacturing capacity around the world, White House Chief of Staff Ron Klain said in an interview on the New York Times’ “Ezra Klein Show,” adding that the administration recognizes the global shortfall. “We are not where we need to be,” Klain said.

    Officials touted a new campaign, led by the U.S. Agency for International Development and initially funded with roughly $500 million, that is now supporting mobile vaccination sites, improving vaccine storage and addressing other logistical needs in low- and middle-income countries.

    “This is a winnable fight,” said Jeremy Konyndyk, executive director of USAID’s covid-19 task force, saying that recent spikes in vaccination rates in African countries such as Zambia, Ghana and Ivory Coast show “proof of concept” for the U.S. strategy. For instance, 22 percent of people in Ghana have now received at least one dose of coronavirus vaccine, after vaccination rates were stalled below 8 percent for most of 2021, according to data tracked by Oxford University’s Our World in Data project.

    “They’ve all been able to deliver significant improvements in vaccine uptake when they have gotten infusions of resources,” Konyndyk said. White House officials confirmed they are targeting late March for an international summit, led by Biden, intended to hold global leaders accountable for pledges they made last year, including a vow to “fully vaccinate” 70 percent of the world by the fall of 2022. To help lay the groundwork for that meeting, senior officials such as Secretary of State Antony Blinken and Health and Human Services Secretary Xavier Becerra also are preparing to host meetings with their global counterparts, said two people with knowledge of those plans who were not authorized to speak publicly.

    Biden has struggled to deliver on some key pandemic promises

    Gayle Smith, who led the State Department’s coronavirus response last year, said Biden’s strategy is working but remains dependent on international cooperation.

    “We know what it takes,” Smith added. “And we’ve got the skills, the knowledge, the facts and … the resources to do it. We’ve just got to muster the global political will to not just do more but do enough.”

    Public health and international policy experts say the White House’s strategy continues to fall short, warning that the collateral damage from covid-19 remains high as countries reel from disruptions to health systems, social services and the resurgent risk of other infectious diseases such as measles. Meanwhile, a key Biden pledge — to tamp down global virus spread — is far from being met.

    “The big picture, of course, is that we haven’t been able to limit transmission,” said Amanda Glassman, executive vice president of the Center for Global Development, a nonprofit think tank focused on international development. “Cases are increasing everywhere. And viral diversity is therefore increasing. … It’s a very good time to revisit the strategy and to plan for an extended period of several years where we’re going to be more at risk for the emergence of new variants.”

    Congressional Democrats are pushing the White House to immediately request billions of dollars earmarked for the global response as part of a supplemental funding package that could be sent to the Hill this week, warning that some coronavirus stimulus funds are nearly exhausted.

    “USAID — the primary U.S. agency leading global vaccination efforts and the global COVID-19 response — is a little over a month away from running out of money,” Krishnamoorthi, Sen. Elizabeth Warren (D-Mass.) and other Democrats wrote in a letter sent to Biden on Tuesday and shared with The Post.

    White House officials declined questions about specific funding requests, saying they are still assessing the need for further investments.

    Rep. Tom Malinowski (D-N.J.), vice chair of the House Committee on Foreign Affairs, also signed the letter. He said there’s “nothing more important” than prioritizing the global coronavirus response.

    “I’m beside myself about what’s happening in Ukraine,” Malinowski said. “… But if your focus is on America’s foreign policy and you’re not waking up every morning and going to sleep every night thinking about vaccinating the world against covid, then there’s something wrong.”

    Democrats also said they were worried that the omicron variant — which is less deadly than some previous variants — will be prematurely perceived as helping usher in the end of the pandemic, with billions of people around the globe potentially gaining immunity that might help ward off future infections. Some public health experts also have argued that omicron could shift the pandemic toward a more manageable stage. Atul Gawande, a surgeon and author who was sworn in this month as USAID’s assistant administrator for global health, countered that the administration has envisioned multiple scenarios for the omicron wave and what comes next — none of them easy. Gawande said that “the best case is that omicron sweeps through the world quickly,” but that will still leave behind global “testing shortages, enormous demand for the oral antiviral medications that need to be made available, stress on masks, supplies and other critical elements, plus the demand not only for full vaccination but for boosters to roll out across the world.”

    “The worst case is that we have the next variant not be so mild and evade our tests and vaccines,” Gawande added, “almost like starting with an entirely new infection again.”

    (Source: Washington Post)

  • January 26 New York & Dallas E – Edition

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  • January 21 New York & Dallas E – Edition

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  • January 14 New York & Dallas E – Edition

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  • Centers For Disease Control (CDC) urges citizens to wear ‘most protective mask’

    Centers For Disease Control (CDC) urges citizens to wear ‘most protective mask’

    Administration toship 500 million COVID-19 tests for free

    WASHINGTON, D.C. (TIP): The U.S. Centers for Disease Control and Prevention (CDC) on Friday, January 14, revised its guidance for Americans on wearing masks to protect against COVID-19, recommending donning “the most protective mask you can” while stopping short of advocating nationwide usage of N95 respirators.

    The CDC, an agency, critics have accused of offering shifting and confusing guidance amid the pandemic, clarified on its website “that people can choose respirators such as N95s and KN95s, including removing concerns related to supply shortages for N95s.”Americans should “wear the most protective mask you can that fits well and that you will wear consistently,” the CDC added.

    The United States leads the world in COVID-19 deaths — roughly 850,000 — even as it battles a surge of cases involving the fast-spreading Omicron coronavirus variant. Complicating matters is the refusal of some Americans to get vaccinated. President Joe Biden said on Thursday, January 13, that the federal government plans to make “high-quality masks” available to Americans for free. In another step, the White House on Friday said the government will begin shipping 500 million COVID-19 tests to Americans later this month without charge.The CDC said it wants to encourage Americans to wear masks rather than push them to wear the highest-grade face protection. It said that “loosely woven cloth products provide the least protection.”“Masking is a critical public health tool to prevent the spread of COVID-19, and it is important to remember that any mask is better than no mask,” the CDC added.

  • Omicron 105% more transmissible than Delta, say French scientists

    Omicron 105% more transmissible than Delta, say French scientists

    The Omicron Covid-19 variant may be 105 per cent more transmissible than Delta, according to a research by French scientists. The study, published on the medRxiv site and yet to be peer-reviewed, analysed 131,478 tests in France from October 25 to December 18, 2021.

    The team applied statistical models to variant-specific screening tests and full genome sequencing.

    They compared the number of infections with the Omicron, Alpha and the Delta variants over a 21-day period.

    The difference in rate of transmissibility in people with the Delta and Omicron was approximately 105 per cent.

    “We estimate that the transmission advantage of the Omicron variant over the Delta variant is more than 105 per cent,” said Samuel Alizon, from Centre for Interdisciplinary Research in Biology (CIRB) France.

    Further, the results showed that tests consistent with the presence of the Omicron variant exhibit significantly higher cycle threshold Ct values, which could indicate lower amounts of virus genetic material.

    “Epidemiological modelling indicates that even if the virulence of the Omicron variant is reduced compared to that of the Delta variant, the increase in reproduction number we estimate from the data can have the potential to maintain critical Covid-19 activity at a high level in French hospitals, if not overloading them,” Alizon said adding that “swift mitigation of the epidemic wave” is essential.

    The results also showed that in young people, the prevalence of infection with the Omicron variant or the Alpha variant was higher than that of the Delta variant. Omicron was designated a variant “of concern” by the World Health Organization (WHO) in November. Since then it has been detected in more than 100 countries.

    Studies have suggested that compared to previous variants, Omicron is less likely to make people seriously ill. Evidence also shows that Omicron is able to invade the upper respiratory tract easier than the Delta variant, but is less effective at infecting the lungs – a reason why it is more contagious and its mortality lower compared to Delta.

    However, earlier this week, the WHO warned against describing the Omicron variant as “mild” amid a “tsunami of cases” overwhelming health systems across the world.

    “Just like previous variants; Omicron is hospitalising people and killing people,” Tedros Adhanom Ghebreyesus, Director-General of the WHO, said last week.

    “Hospitals are becoming overcrowded and understaffed, which further results in preventable deaths from not only Covid-19 but other diseases and injuries where patients cannot receive timely care”.      Source: IANS

  • Omicron surge could differ per country: WHO

    Top World Health Organization official says low hospitalization and death rates in South Africa due to the omicron variant cannot be considered a template for how the variant will fare as it surges in other countries.

    Dr. Abdi Mahamud, Covid-19 incident manager at the UN health agency, notes a “decoupling” between case counts and deaths in the country, which first announced the emergence of the fast-spreading new variant.

    He said that in terms of hospitalizations South Africa remains “very low, and the death has remained very, very low.”   But Mahamud says “it cannot be extrapolated from South Africa to other countries, because each is country is unique on its own”.  By its latest count, WHO says 128 countries had confirmed cases of the new variant that first emerged in southern Africa in November, but many other places — which may not have complete testing capabilities — are believed to have it too.

    Mahamud notes that omicron has shown nearly unprecedented transmissibility for a virus.

    He notes a “remarkable increase” in cases in the United States, where “we are seeing more and more hospitalizations coming along”. But he did cite an increasing number of studies showing omicron affects the upper part of the body, whereas other versions devastated lung function and caused severe pneumonia that led to many deaths.

    Mahamud says that could be “good news” but that more studies are needed to get a full picture.

    Hospitalisation figures may better reflect Omicron severity: Fauci

    The number of hospitalisations due to the Omicron variant is a better measure to understand its severity than the traditional case-count of new infections, top US infectious disease expert Dr Anthony Fauci has said. Fauci has joined a growing body of experts who argue that case counts ‘don’t reflect what they used to’, as data suggests Omicron is less severe but more contagious, the Guardian reported.

    However, referring to the Omicron surge in the US as a “tsunami”, Fauci also cautioned the public not to be fooled by preliminary data suggesting the variant lacks the severity of earlier Covid-19 variants, such as Delta.

  • Germany mulls new Covid restrictions as Omicron advances

    Germany mulls new Covid restrictions as Omicron advances

    Berlin (TIP): Germany’s leaders are set to consider possible new restrictions and changes to quarantine rules on January 7 as the new Omicron variant advances quickly. Chancellor Olaf Scholz and the country’s 16 state governors are likely to build on restrictions introduced just after Christmas that limited private gatherings to 10 people, among other things.One measure under consideration is toughening a measure that requires people to provide proof of full vaccination or recovery to enter restaurants or bars. They could now be required to provide proof of either a booster shot or a fresh negative test.

    Scholz and the governors also are expected to consider shortening required quarantine or self-isolation periods that are currently as long as 14 days, something that many other countries already have done.

    The Covid-19 situation in Germany has been foggy for the past two weeks because of very patchy testing and slow reporting over the holiday period. Official figures, which authorities have acknowledged don’t yet show the full picture, have shown a steady increase in the infection rate over the past week.

    On Friday, the national disease control centre, the Robert Koch Institute, reported an official rate of 303.4 new cases per 1,00,000 residents over the past seven days. Over the past 24 hours, 56,335 new cases were reported.

    In its weekly report on Thursday, the institute said Omicron accounted for 44.3 per cent of cases tested for variants in Germany last week, up from 15.8 per cent the previous week.

    Germany’s vaccination campaign is regaining speed after the holidays. As of Thursday, 71.5 per cent of the population had received a full first vaccine course and 40.9 per cent had had a booster shot. —AP

  • Weak testing, data outage leave Brazil ‘in the dark’ as Omicron advances

    Rio de Janeiro (TIP): Insufficient testing for Covid-19 and a data blackout caused by hackers have left Brazil in the dark as it grapples with a wave of infections from the Omicron coronavirus variant, health experts warn.

    Brazilians with Covid-19 symptoms are facing long lines to get tested due to the lack of kits in a country without a comprehensive testing strategy since the start of the pandemic.

    Substantial testing and genomic sequencing of confirmed infections are crucial to tracking and fighting the pandemic, especially with the onset of the highly contagious Omicron.

    To make matters worse, some Health Ministry databases have been offline since an apparent ransomware attack seriously hampered the government’s ability to gather data from state health authorities. “In general, the registration system was bad from the start, and it got worse with the hacker attack, so we’re really under water,” said Gonzalo Vecina, former head of Brazilian health regulator Anvisa and professor at the University of Sao Paulo.

    “We’re in the dark,” he said.

    Despite having the world’s third-deadliest outbreak after the United States and Russia, according to Reuters calculations, Brazil tests for Covid-19 far less than South American peers.

    Over the last seven days, Brazil performed an average 0.23 tests per 1,000 inhabitants, according to statistics compiled by the Our World in Data website. By contrast, Argentina applied 2.15 tests per 1,000 people in the same period and Uruguay performed 3.88 tests per 1,000 inhabitants.

    Demand for tests in Brazil surged during year-end holidays and many pharmacies and clinics ran out of kits. Inventory had dwindled as vaccination advanced in the country and cases fell.

    ‘AN EXPRESSIVE INCREASE’

    Despite limited data sources, Covid-19 cases are clearly rising in Brazil. In Rio de Janeiro, the rolling seven-day average of confirmed cases jumped more than 2,000% since mid-December to 398 on Monday.

    “We are seeing an expressive increase in the number of cases, dealing with patients and people in everyday life. And this increase is happening in the places where Omicron has been detected,” said Esper Kallas, a doctor specialized in infectious diseases and professor at the University of Sao Paulo.

    The Health Ministry did not respond to a request for comment on how the cyberattack affected monitoring of the pandemic. Health Minister Marcelo Queiroga has said that data is being collected but not made public.

    The ministry’s website was back online this week, but with numbers only through early December, before it was hacked. Brazil has so far verified just 265 Omicron cases since late November, according to the ministry. Extensive sequencing in other countries showed Omicron quickly became the dominant variant, causing cases to surge in a matter of days.

    The hope, experts say, is that Omicron does not seem as lethal as previous variants and its death toll may be limited in Brazil, where a vaccination campaign.  Reuters

  • January 7 New York & Dallas E – Edition

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  • December 31 New York & Dallas E – Edition

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  • Omicron has a greater capacity to bind with human cells: Study

    Even as the newly reported Omicron variant is poised to replace Delta as the dominant variant across the world, a study led by an Indian-origin researcher shows that many mutations in the variant allow it to bond with human cells far more efficiently than previous strains.

    The Omicron variant was first identified in South Africa in late November, and has since spread rapidly to 106 countries. The variant is now the dominant strain in many countries including the US, the UK, Denmark among others.

    Of all the variants of coronaviruses so far, Omicron is the most heavily mutated with more than 30 mutations on its spike protein, which the virus uses to enter human cells. The variant also harbours a high number of mutations in regions of the spike protein that antibodies recognise, potentially dampening their potency.

    Researchers from the University of British Columbia, Canada, studied Omicron using cryo-electron microscopy — a technique that provides images of the virus at incredibly high resolution.

    The results, published pre-print and not peer-reviewed yet, showed that “Omicron has far greater binding affinity than the original SARS-CoV-2 virus” due to new bonds created between the virus and human cell receptors, Dr Sriram Subramaniam, lead scientist, was quoted as saying to the Daily Mail. In addition, the researchers tested Omicron against human and monoclonal antibodies, finding that the variant is more resistant to these immune system particles than other variants.

    “The Omicron variant is unprecedented for having 37 spike protein mutations – that’s three to five times more mutations than any other variant,” Subramaniam, a biochemistry professor at the University, was quoted as saying in a statement.

    According to Subramaniam, the increased mutations on the spike protein are important for two reasons: “Firstly, because the spike protein is how the virus attaches to and infects human cells. Secondly, because antibodies attach to the spike protein in order to neutralise the virus.” The team probed Omicron’s mutations through microscopic imaging, and found that some of the mutations create additional bonds between the virus and ACE2 receptors – a human cell receptor located throughout the body, the report said.

    These new mutations appear to “increase binding affinity”, Subramaniam said, indicating that Omicron can attach more strongly to human cells.

    The researchers compared Omicron’s binding affinity to that of the Delta variant and the original strain of the coronavirus.

  • Omicron infects 70 times faster but is less severe, says study

    Omicron infects 70 times faster but is less severe, says study

    The yet-to-be peer-reviewed study provides the first information on how the novel variant of concern infects human respiratory tract

    BEIJING (TIP): The Omicron variant of coronavirus infects and multiplies 70 times faster than Delta and the original COVID-19 strain, but the severity of illness is likely to be much lower, according to a study. The yet-to-be peer-reviewed study provides the first information on how the novel variant of concern infects human respiratory tract.

    The researchers from University of Hong Kong found that Omicron infects and multiplies 70 times faster than the Delta variant and original SARS-CoV-2 in human bronchus, which may explain why it may transmit faster between humans than previous variants.

    A bronchus is a passage or airway in the lower respiratory tract that conducts air into the lungs.

    The study also showed that the Omicron infection in the lung is significantly lower than the original SARS-CoV-2, which may indicate lower disease severity.

    The researchers used ex-vivo cultures of the respiratory tract to understand why Omicron may differ in transmission and disease severity from other SARS-CoV-2 variants.

    This method uses lung tissue removed for treatment of the lung, which is normally discarded, for investigating viral diseases of the respiratory tract.

    Michael Chan Chi-wai, Associate Professor at University of Hong Kong, and his team successfully isolated Omicron and compared infection from the variant with the original SARS-CoV-2 from 2020, and the Delta variant. The team found that the Omicron replicates faster than the original SARS-CoV-2 virus and Delta variant in the human bronchus.

    At 24 hours after infection, the Omicron variant replicated around 70 times higher than the Delta variant and the original SARS-CoV-2 virus, the researchers said.

    Omicron replicated less efficiently—over 10 times lower—in the human lung tissue than the original SARS-CoV-2 virus, which may suggest lower severity of disease, they said.

    “It is important to note that the severity of disease in humans is not determined only by virus replication but also by the host immune response to the infection, which may lead to dysregulation of the innate immune system,” Chan said in a statement.

    “It is also noted that by infecting many more people, a very infectious virus may cause more severe disease and death even though the virus itself may be less pathogenic,” he explained.

    Taken together with the recent studies that showed Omicron can partially escape immunity from vaccines and past infection, the overall threat from the variant is likely to be very significant, the researchers added.

    (Source: PTI)