In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease. In this large population-based family study recently published in the American Journal of Kidney Diseases, researchers investigated the familial aggregation of CKD by comparing the risk of chronic kidney disease (CKD) in individuals with an affected first-degree relative to that in the general population. Participants with an affected first-degree relative were observed to have a threefold higher risk of CKD compared to that in the general population, independent of BMI, hypertension, diabetes, hypercholesterolemia, history of cardiovascular disease (CVD), and smoking status. The authors of this study observed a 1.56 fold higher risk in those with an affected spouse, suggesting that shared environmental factors and/or assortative mating play a role. Heritability of eGFR was considerable (44 per cent), whereas heritability of UAE was moderate (20 per cent). Heritability of kidney-related markers and serum electrolytes ranged between 20 and 50 per cent. These results indicate an important role for genetic factors in modulating susceptibility to kidney disease in the general population.
Related Articles
Indigenous people in Brazil shed tears of joy as the Supreme Court enshrines their land rights
RIO DE JANEIRO (TIP): Indigenous people celebrated September 21 after Brazil’s Supreme Court ruled to enshrine their land rights, removing the imminent threat those protections could be rolled back. The justices had been evaluating a […]
Swine Flu outbreak in India with over 16,000 affected & section 144 imposed in Ahmedabad
Swine flu claimed 51 more lives, taking the death toll to 926. The H1N1 virus has, so far, affected more than 16,000 people across the country. According to collated data from the Health Ministry till […]
Be the first to comment